Development of an ultra-sensitive method using nafion and multi-walled carbon nanotube coated glassy carbon electrode for atenolol determination

Atenolol (Scheme 1) is antihypertensive drug that form β-blocker group, which widely used in the treatment of hypertension In this study, the redox properties of the Tensinor drug used in blood pressure treatment were examined on modified glassy carbon electrode and the electrodes prepared by coating carbon nanotubes on this modified electrode. In order to investigate the effects of nafion coated multi-walled glass nanotube (MWCNT / NGCE) electrode response and nafion coated glassy carbon electrode (NGCE) and electrode responses of only glassy carbon electrode (GCE) surfaces on the support electrolyte, pH and scan rate, the cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods were used. Atenolol (ATN) was observed in the Britton-Robinson (BR) buffer solution (pH 7.0) thereabouts 1.11 V (vsAg / AgCl (3.0 mol L-1 KCl). voltammetric method reacted linear at a concentration range between 3x10-5 μM and 9x10-2 μM under optimum analytical experimental conditions. The results of Tensinor's limit of detection on the Britton-Robinson (BR) (pH = 7) buffer were found to be 7.67 x 10-5 mM and 2.5 x 10-4 mM, respectively. Additionaly, in the study, interference effects experiments were performed with auxiliary substances used in the preparation of medicines and no negative effect was observed.

Atenolol tayini için nafion ve çok duvarlý karbon nanotüp kaplý camsý karbon elektrot kullanýlarak ultra hassas yöntem geliþtirilmesi

Atenolol (Þekil 1), hipertansiyon tedavisinde yaygýn olarak kullanýlan β-bloker grubunu oluþturan antihipertansif ilaçtýr. Bu çalýþmada; Tansiyon tedavisinde kullanýlan Tensinör ilacýnýn redoks özellikleri, modifiye camsý karbon elektrot ve bu modifiye elektrot üzerine karbon nano tüp kaplanarak hazýrlanmýþ elektrotlarda incelenmiþtir. Nafion kaplý çok duvarlý karbon nanotüp (MWCNT/NGCE) elektrot yanýtý ile Nafion kaplý camsý karbon elektrot (NGCE) ve sadece camsý karbon elektrot (GCE) yüzeylerinin elektrot yanýtlarýnýn destek elektroliti, pH, ve tarama hýzý üzerine etkilerini araþtýrmak için Çevrimsel voltametri (CV) ve Diferansiyel puls voltametri (DPV) yöntemleri kullanýlmýþtýr. Atenolol (ATN) Britton–Robinson (BR) tampon çözeltisinde (pH 7.0) 1.11 V (vsAg / AgCl (3.0 mol L-1 KC1) civarýnda gözlenmiþtir. Voltametrik yöntem, optimum analitik deney koþullarý altýnda, 3x10-5 µM -9x10-2 mM konsantrasyon aralýðýnda lineer tepki göstermiþtir. Britton–Robinson (BR) (pH=7) tamponundaki Tensinör belirme sýnýrý sonuçlarý, sýrasýyla 7.67 x 10-5 mM ve 2.5 x 10-4 mM olarak bulunmuþtur. Ayrýca çalýþmada ilaçlarýn hazýrlanmasýnda kullanýlan yardýmcý maddeler ile giriþim etkisi deneyleri gerçekleþtirilmiþ ve olumsuz bir etkiye rastlanmamýþtýr.